Vaccine

My wife is in a high risk category. She will be eligible for the vaccine soon. She has friends I believe @ J and J that have been talking about how 'normal' vaccines take 4-5 years to get approved. For that reason, she is afraid and basically won't take it. She won't leave the house. I worry for her physical and at this point her mental well being. I believe some people have made points about how this vaccine is different which is why it was approved so quickly? 
 
Mary Ann from Gilligan's Island died today of COVID.

If that doesn't make you want to get a vaccine, I don't know what will.
 
MainMan" post=410728 said:
Mary Ann from Gilligan's Island died today of COVID.

If that doesn't make you want to get a vaccine, I don't know what will.


Ginger.  Very sorry to hear RIP
 
 
SI1996" post=410727 said:
My wife is in a high risk category. She will be eligible for the vaccine soon. She has friends I believe @ J and J that have been talking about how 'normal' vaccines take 4-5 years to get approved. For that reason, she is afraid and basically won't take it. She won't leave the house. I worry for her physical and at this point her mental well being. I believe some people have made points about how this vaccine is different which is why it was approved so quickly? 

She would be crazy not to take it if she is high risk.  Can't fear both.  The vaccine is good technology and uses synthetic mRNA. It doesn't enter the cell.  The vaccine technology had also been used before.  As a high risk person, she has little to fear from the vaccine and a whole lot to fear from getting the virus.  
 
2 more vaccines potentially coming very soon. Different technology Beast or MCN or Eric would know a lot better than me the tech behind those 2
 
Now, if everyone (fed/state) could figure out the logistics of how to quickly deploy what's been produced.
 
RedStormNC" post=410759 said:
Now, if everyone (fed/state) could figure out the logistics of how to quickly deploy what's been produced.


yeah I dont know what the delay is. My friends that work at hospitals say it's been pretty orderly for them. My guess is once you get the cvs's and walgreens etc fully ramped up things are going to move a lot quicker
 
 
mjmaherjr" post=410751 said:
2 more vaccines potentially coming very soon. Different technology Beast or MCN or Eric would know a lot better than me the tech behind those 2
The J&J and Astra Zeneca are different fromthe first two which are mRNA vaccines while the latter are DNA and use a flu-like virus to enter the cell instead of an artifical coating. This is a more well-studied technology and apparentlhy is not as fragile as the first two. Don't ask me anything else because I am pushing the envelope of my immunology knowledge. Apparently there are 64 vaccines in clinical trials which is quite a lineup -very deep bench.  
 
They are rolling out the AstraZeneca vaccine aggressively here in the U.K. they are giving only the 1st shot and then wait 12 weeks for the second shot. They are hoping to get a good chunk of the population done by Easter. The really important thing is that is just needs a normal refrigerator which means every GP in the country can administer it.
 
gman" post=410779 said:
They are rolling out the AstraZeneca vaccine aggressively here in the U.K. they are giving only the 1st shot and then wait 12 weeks for the second shot. They are hoping to get a good chunk of the population done by Easter. The really important thing is that is just needs a normal refrigerator which means every GP in the country can administer it.

My guess would be those 2 would also be a lot easier to distribute in South America and Africa ( we do need the rest of the world to get vaccinated ). Due to the temperature thing you mentioned and also the cost ( a lot less then Pfizer and Moderna I think )

Ironically I spoke to a friend in Argentina and she thinks as of now the one they will be getting is the Russian one. Surely it will have some crazy thing inside it to make people crave Russian Vodka and helping their export biz. I dont even think Peru has anything lined up so far and they were the second worst country hit in South America although by now most of Lima probably has heard immunity they got it so bad
 
 
ctstorm" post=410776 said:
mjmaherjr" post=410751 said:
2 more vaccines potentially coming very soon. Different technology Beast or MCN or Eric would know a lot better than me the tech behind those 2
The J&J and Astra Zeneca are different fromthe first two which are mRNA vaccines while the latter are DNA and use a flu-like virus to enter the cell instead of an artifical coating. This is a more well-studied technology and apparentlhy is not as fragile as the first two. Don't ask me anything else because I am pushing the envelope of my immunology knowledge. Apparently there are 64 vaccines in clinical trials which is quite a lineup -very deep bench.  
Two things I very much like about you:  your humility, and readiness to admit the boundaries of your expertise.   When you left St. John's the university lost an incredibly engaging professor who made a very difficult course fun and interesting and humorous.    I know people here like to post under a veil of anonymity, so I hope I haven't blown yours by acknowledging that you are perhaps one of the best professors SJU has ever had in the college of pharmacy.   I will stop by not explaining where you taught for the bulk of your career, lol.
 
Guess I just got knocked out with my Father Harrington pick in the " who is ctstorm " pool :)
 
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The government should have thought a little more outside the box and have vaccines shipped to McDonald's and Taco Bell's. Drive through get a Chalupa or McMuffin and get a vaccine shot as part of the value meals. Trump loves McDonald's so not sure why I have to come up with brilliant ideas like this when I'm hungry :)
 
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Beast:

Thanks for your respnse, which I would imagine just narrowly qualifies as a non-political post. 

Regarding Pfizer, they got a $1.95 billion deal with the government’s Operation Warp Speed to deliver 100 million doses of the vaccine. The arrangement is an advance-purchase agreement, meaning that the company doesn’t get paid until/unless they deliver the vaccines. Pfizer did not accept federal funding to help develop or manufacture the vaccine, unlike front-runners Moderna and AstraZeneca. ([URL]https://www.nytimes.com/2020/11/10/health/was-the-pfizer-vaccine-part-of-the-governments-operation-warp-speed.html[/URL]]NY Times -11/10/20[/url])

As far as vaccine distribution, this is the most significant health/economic crisis of our lifetimes.  The federal government took the lead on purchasing and now controls supply of the vaccine which is the most critical resource on the planet.  "Leaving it up to the states" has already proven to be a failed approach when it comes to pandemic response.  The federal government needs to execute with more urgency and, whether they like it or not, they do bare responsibility for this rollout.  If their strategy is "leaving it up to the states" and that fails, they are responsibile.  The governement's chief function is to protect it's people.

Yes, CTstorm read my post correctly, I was referring to AstraZeneca's trial reports (not Moderna).  But, considering your graduate course, I will defer to you on that.    
 
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Beast of the East" post=410810 said:
ctstorm" post=410776 said:
mjmaherjr" post=410751 said:
2 more vaccines potentially coming very soon. Different technology Beast or MCN or Eric would know a lot better than me the tech behind those 2
The J&J and Astra Zeneca are different fromthe first two which are mRNA vaccines while the latter are DNA and use a flu-like virus to enter the cell instead of an artifical coating. This is a more well-studied technology and apparentlhy is not as fragile as the first two. Don't ask me anything else because I am pushing the envelope of my immunology knowledge. Apparently there are 64 vaccines in clinical trials which is quite a lineup -very deep bench.  
Two things I very much like about you:  your humility, and readiness to admit the boundaries of your expertise.   When you left St. John's the university lost an incredibly engaging professor who made a very difficult course fun and interesting and humorous.    I know people here like to post under a veil of anonymity, so I hope I haven't blown yours by acknowledging that you are perhaps one of the best professors SJU has ever had in the college of pharmacy.   I will stop by not explaining where you taught for the bulk of your career, lol.
Thanks and I greatly admire what you have accomplished over the years, Very impresive. Now we should stop the mutual adulatoin before everyine else starts geting  queasy. 
 
You guys have answered Maher as well as I could.   Let's just hope they all work and get into everyone ASAP.   Happy new year all!!
 
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