A wide berth here about what constitutes a big man. Many of these players (Berry, Williams, Burrell, Grant, Glover, etc.) were not true centers, even though they played there in college. Others (Allen, Owens, Obepka, etc.) were very limited in terms of time here or playing time. If you limit it to true centers who played full careers here, in the post 1975ish era, IMHO (probably missing someone):
1. Joel Soriano
2. Zendon Hamilton
3. Lamont Hamilton
4. Werdann
5. Wennington
6. Wayne McKoy
7. Shawnelle Scott
But, some of the best we've had here at the position (adjusted for the eras they played in) were probably pre-1975 - guys like Zawoluk, George Johnson, Ellis, etc.